HIV and Leukemia Cured!

HIV case believed cured

German doctors implanted stem cells

Doctors in Berlin, working with an American patient with both HIV and leukemia, have declared in a peer-reviewed medical journal that they believe they have cured both illnesses. It would be the first time an HIV- Leukemia patient has been cured.

The procedure is creating a buzz in the HIV academic community in the United States. Experts here call the development encouraging, but warn that years of work remain before the treatment could lead to a general therapy against HIV.

“ ‘Cured’ is a strong word. But this is very encouraging,” said Dr. David Scadden, co-director of the Harvard University Stem Cell Institute. “From all indications, there was no residual virus.”

HIV/AIDS, first recognized in the United States in 1981, was almost always a death sentence until the mid-1990s, when powerful anti-retroviral drugs were developed to hold it mostly in check.

“I would call this a functional cure,” said Dr. Margaret Fischl, pioneering AIDS researcher at the University of Miami. “It’s on the level and a very remarkable case. But would we do this with an HIV patient? No.”

The treatment is too radical, its side effects too harsh for general use, Fischl said. Still, it opens up new avenues for researchers to create more practical cures, she said.

In 2007, a 44-year-old American named Timothy Ray Brown, who had both HIV and leukemia, was set to undergo stem cell therapy in Berlin to fight his leukemia. But Dr. Gero Huetter and colleagues at Charite-University Medicine Berlin decided to perform a stem cell transplant that also might help against his HIV.

They used stem cells from a donor who had an inherited gene mutation that left his body without the gene receptors involved in contracting HIV, making him naturally resistant to the virus.

On the day of the transplant, Brown stopped taking the antiretroviral drugs that had been keeping his HIV in check. In February 2009 the doctors reported in the New England Journal of Medicine that Brown’s HIV had not rebounded in the first 20 months after the transplant.

Still, some doctors suspected, based on past experience, that the HIV virus remained hiding in his body. But in the new report this week in the journal Blood, the doctors say that 3 1/2 years after the transplant, Brown’s cell counts remain in the range of people without HIV.

“In conclusion,” they wrote, “our results strongly suggest that cure of HIV has been achieved in this patient.”

Brown also shows no evidence of leukemia, the doctors say.None.

Link:

http://www.spokesman.com/stories/2010/dec/15/hiv-case-believed-cured/